Lücker P W, Simon B, Talmont D M
Arzneimittelforschung. 1978;28(1):79-82.
The study deals with the bioavailability of a newly developed vincamine multi-layer dragee (Pervincamin forte retard) which showed an extremely continuous release of the active principle in vitro. Furthermore the correlation between half-life and age of the volunteers was to be established. The investigations were performed on six volunteers. After GC analysis of the vincamine-serum concentration the following pharmacokinetic profile could be established: The substance appears in the streaming blood with an invasion half-life of 53 min. The maximum is reached after 3 h. After oral application of 16 mg the concentration will amount to 36 ng/ml. The apparent elimination half-life caused by the sustained release from of the multi-layer dragee was 9.13 h. 24 h after application there was still a mean serum concentration of 5.74 ng/ml to be detected. Between age of the subjects and serum half-life is a marked linear correlation.
该研究涉及一种新开发的长春胺多层糖衣丸（缓释强力长春胺）的生物利用度，其在体外显示出活性成分的极其持续释放。此外，还需确定志愿者的半衰期与年龄之间的相关性。研究在六名志愿者身上进行。通过气相色谱分析长春胺血清浓度后，可建立以下药代动力学特征：该物质在流动血液中出现的侵入半衰期为53分钟。3小时后达到最大值。口服16毫克后，浓度将达到36纳克/毫升。由多层糖衣丸的持续释放引起的表观消除半衰期为9.13小时。用药后24小时仍可检测到平均血清浓度为5.74纳克/毫升。受试者年龄与血清半衰期之间存在明显的线性相关性。
