Fiedel B A, Gewurz H
J Immunol. 1976 May;116(5):1289-94.
C-reactive protein (CRP) is an acute phase reactant which shares numerous functional characteristics with the immunoglobulins. In the present study CRP was found to inhibit the aggregation of human platelets stimulated by either modified human immunoglobulin or thrombin. This effect did not involve chelation of calcium or cytotoxicity, and was overcome by larger amounts of the aggregating agents. CRP also inhibited the activation but not the activity of platelet factor 3 and the release of beta-glucuronidase. Thus, CRP can inhibit multiple platelet reactivities. We suggest that this property of CRP may play an important role in the control of platelet responsiveness during reactions of inflammation, defense, and repair.
C反应蛋白（CRP）是一种急性期反应物，与免疫球蛋白具有许多功能特性。在本研究中，发现CRP可抑制由修饰的人免疫球蛋白或凝血酶刺激的人血小板聚集。这种作用不涉及钙螯合或细胞毒性，并且会被大量的聚集剂所克服。CRP还抑制血小板因子3的激活而非活性以及β-葡萄糖醛酸酶的释放。因此，CRP可抑制多种血小板反应性。我们认为，CRP的这一特性可能在炎症、防御和修复反应过程中对血小板反应性的控制中发挥重要作用。
