Salminen L
Acta Ophthalmol (Copenh). 1978 Feb;56(1):20-6. doi: 10.1111/j.1755-3768.1978.tb00464.x.
The effect of anterior chamber puncture on cloxacillin concentration in the rabbit eye after intravenous injection was studied using a radioactive tracer method. The enhancement in drug concentration caused by paracentesis was most immediate and significant in the iris-ciliary body preparation. It was soon followed by high cloxacillin concentration in the aqueous humour, which contributed to elevated cloxacillin levels in the cornea, lens and anterior vitreous body, when compared to normal material. Contrary to normal eyes, cloxacillin concentration in the cornea of the punctured eyes was higher than in the limbal area. The morphological changes occurring after paracentesis are discussed. The breakdown of the hydrodynamic equilibrium in the eye, suggested as the only change after paracentesis by Raviola (1974), cannot merely explain the cloxacillin concentration changes measured in the punctured eye.
采用放射性示踪法研究了前房穿刺对静脉注射后兔眼氯唑西林浓度的影响。在前房穿刺引起的药物浓度升高在虹膜睫状体标本中最为迅速和显著。随后房水中很快出现高氯唑西林浓度，与正常标本相比，这导致角膜、晶状体和眼前玻璃体中氯唑西林水平升高。与正常眼相反，穿刺眼的角膜中氯唑西林浓度高于角膜缘区域。讨论了前房穿刺后发生的形态学变化。Raviola（1974年）提出的前房穿刺后唯一的变化——眼内流体动力学平衡的破坏，不能仅仅解释在穿刺眼中测得的氯唑西林浓度变化。
