Kummen M, Lie K K, Lie S O
Acta Pharmacol Toxicol (Copenh). 1978 Mar;42(3):212-8. doi: 10.1111/j.1600-0773.1978.tb02192.x.
The pharmacokinetics of adriamycin given as free and in DNA-complexed form was compared in six children with malignant disease. The two types of adriamycin were given to the same child at 3--4-week intervals, thereby excluding genetic variations when comparing the results. Plasma and urine were collected during and after the drug infusion, and the drug concentrations were measured by means of a sensitive fluorimetric procedure. The study shows that one obtains: 1. a much higher plasma concentration of adriamycin when it is given in the complexed form. 2. a lower urine excretion of adriamycin and fluorescent metabolites when adriamycin is administered as the DNA-complex.
在6名患有恶性疾病的儿童中比较了游离形式和与DNA复合形式阿霉素的药代动力学。两种类型的阿霉素以3至4周的间隔给予同一儿童，从而在比较结果时排除了基因变异的影响。在药物输注期间及之后收集血浆和尿液，并通过灵敏的荧光法测量药物浓度。研究表明：1. 当以复合形式给予阿霉素时，其血浆浓度要高得多。2. 当阿霉素作为DNA复合物给药时，其尿液排泄量以及荧光代谢产物排泄量较低。
