Alward C T, Hook J B, Helmbrath T A, Bailie M D
Pediatr Res. 1978 Mar;12(3):225-8. doi: 10.1203/00006450-197803000-00013.
This investigation was undertaken to determine the nature of acute alterations in renal function following the production of hypoxemia, hypercarbia, and acidosis in newborn piglets 6-96 hr of age. After completion of the surgical procedure piglets were allowed to recover from the effects of anesthesia. When respiratory dead space was increased arterial oxygen tension decreased whereas arterial carbon dioxide tension and hydrogen ion concentration increased. There was little change in glomerular filtration rate. Total renal blood flow decreased and renal vascular resistance increased significantly (504 +/- 78 mm Hg/liter/mm/m2 to 1422 +/- 504). There was no change in distribution of intrarenal blood flow. Sodium excretion and urinary flow rate demonstrated significant parallel increases following the increase in dead space. Plasma renin concentration increased from 67 to 110 ng/ml.
本研究旨在确定6至96小时龄新生仔猪出现低氧血症、高碳酸血症和酸中毒后肾功能急性改变的性质。手术完成后，让仔猪从麻醉效果中恢复。当呼吸道死腔增加时，动脉血氧张力降低，而动脉二氧化碳张力和氢离子浓度增加。肾小球滤过率变化不大。肾总血流量减少，肾血管阻力显著增加（从504±78毫米汞柱/升/毫米/平方米增至1422±504）。肾内血流分布无变化。死腔增加后，钠排泄和尿流率显著平行增加。血浆肾素浓度从67纳克/毫升增至110纳克/毫升。
