Rognum T O, Bjerve K S, Seip M, Trygstad O, Oseid S
Acta Endocrinol (Copenh). 1978 May;88(1):182-9. doi: 10.1530/acta.0.0880182.
Fat cell size and lipid composition of subcutaneous tissue from 3 patients with congenital generalized lipodystrophy have been measured before and after treatment with either pimozide, fenfluramine or hypophysectomy. The fat cell volume before treatment ranged between 9.8 x 10(4) and 17.7 x 10(4) micron 3, compared to 9.0 x 10(4) and 85.3 x 10(4) micron 3 in 15 controls. The amount of lipids was only 1/10 to 1/50 of normal, triglycerides being the most heavily reduced lipid component. Neither the fat cell size nor the lipid content were affected by treatment with hypophysectomy, pimozide or fenfluramine.
对3例先天性全身性脂肪营养不良患者皮下组织的脂肪细胞大小和脂质成分在使用匹莫齐特、芬氟拉明治疗或垂体切除术前、后进行了测量。治疗前脂肪细胞体积在9.8×10⁴至17.7×10⁴立方微米之间，相比之下，15名对照者的脂肪细胞体积为9.0×10⁴至85.3×10⁴立方微米。脂质含量仅为正常水平的1/10至1/50，甘油三酯是减少最为显著的脂质成分。垂体切除、匹莫齐特或芬氟拉明治疗均未影响脂肪细胞大小或脂质含量。
