儿童血清生长激素放射受体分析与放射免疫分析的相关性研究。II：原发性、遗传性及宫内生长迟缓

Correlative study of radioreceptor assay and radioimmunoassay of serum growth hormone in children. II: Primary, genetic and intra-uterine growth retardation.

作者信息

Garnier P E, Repellin A M, Job J C

出版信息

Acta Endocrinol (Copenh). 1978 Jun;88(2):227-38. doi: 10.1530/acta.0.0880227.

DOI:10.1530/acta.0.0880227

Abstract

Growth hormone (GH) was measured by radioreceptorassay (RRA) and radioimmunoassay (RIA) in the sera of 24 children with idiopathic primary growth retardation (PGR), 15 with genetic short stature (GSS) and 11 with intra-uterine growth retardation (IUGR), and compared to results obtained in normal children. The average RRA/RIA ratio was close to normal in PGR (1.02 +/- 0.05) and in IUGR (1.06 +/- 0.07), and slightly though not significantly lower in GSS (0.86 +/- 0.06). Some variability in RRA/RIA ratio was found in individual patients of each group, and some sera gave a non-parallel displacement of the tracer when compared to the standard curve. But no genetic difference of RRA-assayable GH was found between the three groups studied and normal children.

摘要

采用放射受体分析法（RRA）和放射免疫分析法（RIA）对24例特发性原发性生长迟缓（PGR）患儿、15例遗传性身材矮小（GSS）患儿和11例宫内生长迟缓（IUGR）患儿的血清生长激素（GH）进行检测，并与正常儿童的检测结果进行比较。PGR组（1.02±0.05）和IUGR组（1.06±0.07）的平均RRA/RIA比值接近正常，GSS组略低（0.86±0.06），但差异无统计学意义。每组个别患者的RRA/RIA比值存在一定差异，与标准曲线相比，部分血清示踪剂呈非平行位移。但在所研究的三组患儿与正常儿童之间，未发现RRA可检测的GH存在遗传差异。