Tschang T P, Kasin J V, Parnell D, Kraus F T
Arch Pathol Lab Med. 1978 Aug;102(8):426-30.
During the course of applying electron microscopy to diagnostic surgical pathological specimens, three malignant tumors (malignant melanoma, fibrous mesothelioma, lymphoblastic lymphoma) were found to contain annulate lamellae, distinctive intracytoplasmic organelles composed of membrane stacks interrupted by constrictions or pores. In one case both annuli and lamellae were present, a combination rarely described in human tissue and in animal models. In this material, the annuli of the annulate lamellae were structurally similar to nuclear pores. It is postulated that the abundant fibrils are probably related to the unusual configuration of the annulate lamellae. A morphologic relationship of the annulate lamellae to both the endoplasmic reticulum (cases 1 and 2) and the nuclear membrane (case 3) supports the theory that annulate lamellae may be related to both of these structures.
在将电子显微镜应用于诊断性外科病理标本的过程中，发现三种恶性肿瘤（恶性黑色素瘤、纤维性间皮瘤、淋巴细胞性淋巴瘤）含有环状片层，这是一种独特的胞质内细胞器，由被收缩或孔隙中断的膜堆叠组成。在一个病例中，环状结构和片层都存在，这种组合在人体组织和动物模型中很少被描述。在这种材料中，环状片层的环状结构在结构上与核孔相似。据推测，丰富的纤维可能与环状片层的异常构型有关。环状片层与内质网（病例1和2）和核膜（病例3）的形态学关系支持了环状片层可能与这两种结构都有关的理论。
