Linder-Horowitz M
Biochem J. 1969 Aug;114(1):65-70. doi: 10.1042/bj1140065.
The activities of two phosphate-dependent glutaminase reactions characteristic of adult rat liver and kidney were determined in these organs from 2(1/2) days before to 7 days after birth and compared with the activities in the adult tissues. In the kidney, before and after birth, only the kidney type of activity was detected, and it increased in concentration in parallel with the steady growth of that organ throughout the period examined. In the liver, however, the kidney type of activity was the only one present 2(1/2) days before birth, and its concentration decreased to barely significant values by the end of the first week after birth. In contrast, the liver type of activity appeared only just before birth and increased to 60% of adult values over the next 4 days. There was no obvious relation between these changes in glutaminase type and changes in liver weight, protein content and total cell number that occurred during this time. But there was a very close correlation between the fall in kidney-type activity and the estimated fall in haematopoietic-cell number in liver.
在出生前2.5天至出生后7天的大鼠肝脏和肾脏中，测定了成年大鼠肝脏和肾脏特有的两种磷酸依赖性谷氨酰胺酶反应的活性，并与成年组织中的活性进行了比较。在肾脏中，出生前后仅检测到肾脏型活性，并且在整个检查期间，其浓度随着该器官的稳定生长而平行增加。然而，在肝脏中，出生前2.5天仅存在肾脏型活性，到出生后第一周结束时，其浓度降至几乎无显著意义的值。相反，肝脏型活性仅在出生前才出现，并在接下来的4天内增加到成年值的60%。在此期间，谷氨酰胺酶类型的这些变化与肝脏重量、蛋白质含量和总细胞数的变化之间没有明显的关系。但是，肾脏型活性的下降与肝脏中造血细胞数量的估计下降之间存在非常密切的相关性。
