Influence of citalopram and chlorimipramine on uptake of 5-HT by isolated perfused guinea pig lungs.
作者信息
Fjalland B
出版信息
Acta Pharmacol Toxicol (Copenh). 1978 May;42(5):377-80. doi: 10.1111/j.1600-0773.1978.tb02220.x.
Abstract
A method is described for the preparation and perfusion in vitro of isolated guinea pig lungs, 5-HT is rapidly taken up from a perfusing solution by the organ (about 70% uptake). In the concentration range 10(-7) to 5 X 10(-6) M citalopram concentration dependently inhibited the uptake of 5-HT by the lung preparation. Chlorimipramine inhibited the uptake of 5-HT only by 40--50%, and the inhibition was not concentration dependent. The method used seems to be a reliable model for studying the uptake of 5-HT.
摘要
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