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对正常小鼠及感染曼氏血吸虫并用海恩酮治疗的小鼠膀胱中β-葡萄糖醛酸酶的生化研究

Biochemical studies on beta-glucuronidase in the urinary bladder of normal and Schistosoma mansoni infected mice treated with hycanthone.

作者信息

Saad A A, El-Zoghby S M, Farag H F, el-Sewedy S M, Girgis L H, Moghazy M

出版信息

Acta Vitaminol Enzymol. 1977;31(6):183-6.

PMID:581137
Abstract

beta-Glucuronidase activity is elevated in the urine of patients with bilharziasis hematobium. In the present study the enzyme level was estimated in whole urinary bladder tissue homogenates of mice experimentally infected with Schistosoma mansoni. In the infected mice the enzyme activity is significantly higher than in the controls. The effect of the schistosomicidal drug hycanthone was also evaluated. Treatment with the drug did not affect the level of the enzyme activity in the infected mice; it induced an increase in the enzyme activity of the controls.

摘要

埃及血吸虫病患者尿液中的β-葡萄糖醛酸酶活性升高。在本研究中,对实验感染曼氏血吸虫的小鼠全膀胱组织匀浆中的该酶水平进行了测定。在感染小鼠中,该酶活性显著高于对照组。还评估了杀血吸虫药物海恩酮的作用。用该药物治疗对感染小鼠的酶活性水平没有影响;它导致对照组的酶活性增加。

相似文献

1
Biochemical studies on beta-glucuronidase in the urinary bladder of normal and Schistosoma mansoni infected mice treated with hycanthone.对正常小鼠及感染曼氏血吸虫并用海恩酮治疗的小鼠膀胱中β-葡萄糖醛酸酶的生化研究
Acta Vitaminol Enzymol. 1977;31(6):183-6.
2
Biochemical studies on beta-glucuronidase enzyme in liver and spleen homogenates of normal and Schistosoma mansoni infected mice treated with hycanthone.
Biochem Pharmacol. 1978 Feb 15;27(4):473-4. doi: 10.1016/0006-2952(78)90379-9.
3
beta-Glucuronidase activity in liver and spleen homogenates of mice experimentally infected with Schistosoma mansoni.曼氏血吸虫实验感染小鼠肝脏和脾脏匀浆中的β-葡萄糖醛酸酶活性
Acta Vitaminol Enzymol. 1977;31(6):179-82.
4
Clinical treatment of schistosomiasis mansoni with a new schistosomicidal agent: hycanthone or etrenol.用新型杀血吸虫药海恩酮或乙磺半胱氨酸对曼氏血吸虫病进行临床治疗。
J Trop Med Hyg. 1976 Jan;79(1):18-21.
5
Use of praziquantel in patients with schistosomiasis mansoni previously treated with oxamniquine and/or hycanthone: resistance of Schistosoma mansoni to schistosomicidal agents.吡喹酮在先前接受过奥沙尼喹和/或海恩酮治疗的曼氏血吸虫病患者中的应用:曼氏血吸虫对杀血吸虫剂的耐药性
Trans R Soc Trop Med Hyg. 1982;76(5):652-9. doi: 10.1016/0035-9203(82)90235-8.
6
[Immunoglobulins level in patients with schistosomiasis mansoni after hycanthone treatment].[曼氏血吸虫病患者经海蒽酮治疗后的免疫球蛋白水平]
G E N. 1977 Oct-Dec;32(2):141-51.
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Long-term hepatocellular effects of hycanthone and of two other anti-Schistosomal drugs in mice infected with Schistosoma mansoni.海恩酮及其他两种抗曼氏血吸虫病药物对感染曼氏血吸虫的小鼠肝脏的长期影响。
J Pharmacol Exp Ther. 1976 Jun;197(3):703-13.
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Clinical evaluation of niridazole and hycanthone in schistosomiasis mansoni endemic areas.硝唑咪和海蒽酮在曼氏血吸虫病流行区的临床评估
J Toxicol Environ Health. 1975 Nov;1(2):203-9. doi: 10.1080/15287397509529322.
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[Treatment of schistosomiasis mansoni with hycanthone (our experience in 3,500 cases)].
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Comparative effects of hycanthone in Schistosoma mansoni and Schistosoma japonicum.
Am J Trop Med Hyg. 1977 Mar;26(2):238-42. doi: 10.4269/ajtmh.1977.26.238.