Börzsönyi M, Pintér A, Surján A, Török G
Cancer Lett. 1978 Aug;5(2):107-13. doi: 10.1016/s0304-3835(78)80053-6.
Adult Swiss mice were treated intragastrically during the last week of pregnancy with the fungicide dodecylquanidine acetate (dodine, DGA) together with 0.05% sodium nitrite. The incidence of malignant lymphomas, lung adenomas and hepatomas was 30--70% in females. The first tumors appeared 4 months after delivery in the FO generation and at 6--7 months in the F1 generation. Among the untreated control mice the frequency of spontaneous tumors was 6%, and lymphomas developed, if at all, only after 10 months. The oncogenic activity of DGA with sodium nitrite in the offspring was dependent on the dose of DGA.A and C type RNA virus particles were demonstrated in lymphomas by electronmicroscopy. DGA alone had no effect on the cancer incidence.
成年瑞士小鼠在怀孕的最后一周接受胃内给药，给予杀真菌剂醋酸十二烷基胍（多果定，DGA）以及0.05%的亚硝酸钠。雌性小鼠中恶性淋巴瘤、肺腺瘤和肝癌的发生率为30%至70%。第一代（F0）在分娩后4个月出现首批肿瘤，而在F1代中则在6至7个月出现。在未处理的对照小鼠中，自发肿瘤的发生率为6%，淋巴瘤若出现，也仅在10个月后才发生。DGA与亚硝酸钠对后代的致癌活性取决于DGA的剂量。通过电子显微镜在淋巴瘤中发现了A和C型RNA病毒颗粒。单独使用DGA对癌症发生率没有影响。
