Meban C
Respir Physiol. 1978 May;33(2):219-27. doi: 10.1016/0034-5687(78)90071-3.
The surface shear viscosity of films of human lung surfactant was measured using a rotary traction viscometer. At low shear rates dilute surfactant films (surface coverage 2.5--10 cm2/microgram lung extract) exhibited a low viscosity. Increasing the film concentration initially produced only a small increase in viscosity but, after a certain concentration, the film viscosity increased very markedly. The viscosity range for the most disperse (coverage 10 cm2/microgram extract) to the most concentrated film (0.6 cm2/microgram extract) was about 2.0 X 10(-4) g . sec-1 to 2.2 X 10(-2) g . sec-1. Surfactant film viscosity was also found to depend on the temperature of the subphase, higher viscosities being achieved when the subphase temperature was lowered. At low surface concentrations, surfactant films behaved in a strictly Newtonian manner. In contrast, at concentrations above 5.5 cm2/microgram extract they showed mildly non-Newtonian behaviour in that the magnitude of their surface viscosity was dependent on the rate of shear. The results suggest that films of human lung surfactant probably consist of both lipids and protein, and that the protein fraction plays a major part in determining the rheological properties of the films.
使用旋转牵引粘度计测量人肺表面活性剂膜的表面剪切粘度。在低剪切速率下，稀释的表面活性剂膜（表面覆盖率为2.5 - 10平方厘米/微克肺提取物）表现出低粘度。增加膜浓度最初仅使粘度略有增加，但在一定浓度之后，膜粘度显著增加。从最分散的膜（覆盖率为10平方厘米/微克提取物）到最浓缩的膜（0.6平方厘米/微克提取物），粘度范围约为2.0×10⁻⁴克·秒⁻¹至2.2×10⁻²克·秒⁻¹。还发现表面活性剂膜粘度取决于亚相的温度，当亚相温度降低时可达到更高的粘度。在低表面浓度下，表面活性剂膜表现出严格的牛顿流体行为。相比之下，在浓度高于5.5平方厘米/微克提取物时，它们表现出轻度的非牛顿流体行为，即其表面粘度的大小取决于剪切速率。结果表明，人肺表面活性剂膜可能由脂质和蛋白质组成，并且蛋白质部分在决定膜的流变学性质中起主要作用。
