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移植物抗宿主抑制:使用胎儿肝脏和胸腺细胞以将继发性疾病降至最低。

Graft versus host inhibition: fetal liver and thymus cells to minimize secondary disease.

作者信息

Bortin M M, Saltzstein E C

出版信息

Science. 1969 Apr 18;164(3877):316-8. doi: 10.1126/science.164.3877.316.

Abstract

Long-lived radiation chimeras were produced in mice diflering at the major histocompatibility locus. Survival occurred in lethally irradiated recipients inoculated with allogeneic fetal liver and allogeneic fetal thymus cells in combination. The survival rate was equal or superior to that of mice with transplanted syngeneic fetal, neonatal, or adult hematopoietic cells.

摘要

在主要组织相容性位点存在差异的小鼠中产生了长寿辐射嵌合体。在接受致死剂量照射的受体中,联合接种同种异体胎儿肝脏和同种异体胎儿胸腺细胞后出现了存活情况。存活率与移植了同基因胎儿、新生儿或成年造血细胞的小鼠相同或更高。

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