Loz'mian L I
Antibiotiki. 1978 Nov;23(11):1015-7.
Interaction of sibiromycin with chromatin from NK/Li cells was studied. It was shown that the chromatin proteins had no significant effect on the amount of the antibiotic firmly bound with DNA. The difference observed in the kinetics of the sibiromycin interaction with chromatin and DNA from NK/Li cells was not induced by replacement of a part of the DNA bound proteins. Possibly the chromatin proteins hampered formation of DNA conformation necessary for sibiromycin binding.
研究了西伯利亚霉素与NK/Li细胞染色质的相互作用。结果表明，染色质蛋白对与DNA紧密结合的抗生素量没有显著影响。西伯利亚霉素与NK/Li细胞染色质和DNA相互作用动力学中观察到的差异并非由部分与DNA结合的蛋白质的置换所诱导。染色质蛋白可能阻碍了西伯利亚霉素结合所需的DNA构象的形成。
