Hayes A W, Ho I K
J Environ Pathol Toxicol. 1978 Mar-Apr;1(4):491-500.
Rubratoxin B, a metabolite of Penicillium rubrum, is a potent mycotoxin that produces hepatic mid-zonal necrosis. Using propylene glycol as the solvent, the acute LD50 (i.p.) in male mice was estimated at 1.42 mg/kg. Pretreatment with s.c. pellets of pentobarbital reduced this toxicity approximately 42 percent, while castration and SKF 525A pretreatment enhanced toxicity approximately 20 percent and 60 percent, respectively. These studies also demonstrated that rubratoxin B potentiated pentobarbital-induced narcosis and enhanced pentobarbital hypothermia. The effect of SKF-525A and pentobarbital on the LD50 value of rubratoxin B suggests that the toxicity of this mycotoxin in mice does not arise from a toxic metabolite but from the parent compound.
红青霉素毒素B是红青霉的一种代谢产物，是一种强效霉菌毒素，可导致肝脏中区坏死。以丙二醇为溶剂，估计雄性小鼠经腹腔注射的急性半数致死剂量（LD50）为1.42毫克/千克。皮下植入戊巴比妥颗粒进行预处理可使这种毒性降低约42%，而阉割和SKF 525A预处理则分别使毒性增强约20%和60%。这些研究还表明，红青霉素毒素B可增强戊巴比妥引起的麻醉作用，并加剧戊巴比妥导致的体温过低。SKF - 525A和戊巴比妥对红青霉素毒素B的LD50值的影响表明，这种霉菌毒素对小鼠的毒性并非源于有毒代谢产物，而是源于母体化合物。
