Flint B A, Ho I K, Mo B P, Rigor B M
Clin Toxicol. 1979;15(2):169-79. doi: 10.3109/15563657908989862.
The effect of Dopram (doxapram hydrochloride, A. H. Robins Co.) on the pharmacologic responses to pentobarbital was evaluated. In naive and pentobarbital-tolerant mice, Dopram was shown to enhance significantly sodium pentobarbital-induced narcosis in a dose-related manner. The effect of the duration of action of Dopram on pentobarbital narcosis also was assessed. It was observed that Dopram (40 mg/kg, i.p.) significantly increased pentobarbital-induced narcosis even when administered 2 hr prior to challenge with sodium pentobarbital (60 mg/kg, i.p.) A significantly increased hypothermic response to sodium pentobarbital was seen in Dopram-treated animals. The half-life of pentobarbital in brain and serum was shown to be increased significantly in animals receiving Dopram, 40 mg/kg, i.p. The waking brain and serum pentobarbital concentrations were not significantly different in either group. These studies show that Dopram potentiates pentobarbital's effects. Further study is necessary to determine the sites of operation and mechanism of this potentiation.
评估了多普兰（盐酸多沙普仑，A.H.罗宾斯公司）对戊巴比妥药理反应的影响。在未接触过戊巴比妥和对戊巴比妥耐受的小鼠中，多普兰被证明能以剂量相关的方式显著增强戊巴比妥钠诱导的麻醉作用。还评估了多普兰作用持续时间对戊巴比妥麻醉的影响。观察到，即使在腹腔注射戊巴比妥钠（60mg/kg）进行刺激前2小时腹腔注射多普兰（40mg/kg），多普兰也能显著增强戊巴比妥诱导的麻醉作用。在接受多普兰治疗的动物中，观察到对戊巴比妥钠的体温过低反应显著增强。腹腔注射40mg/kg多普兰的动物，其脑中戊巴比妥和血清戊巴比妥的半衰期显著延长。两组动物清醒时脑中及血清中的戊巴比妥浓度无显著差异。这些研究表明多普兰增强了戊巴比妥的作用。需要进一步研究以确定这种增强作用的作用部位和机制。
