Berlowitz L, Pallotta D, Sibley C H
Science. 1969 Jun 27;164(3887):1527-9. doi: 10.1126/science.164.3887.1527.
The degree of actinomycin D binding to DNA in chromatin is dependent upon the state of repression of chromatin. Living cells bind three times more tritiated actinomycin to euchromatin than to genetically inactive heterochromatin. Extraction of histone results in a general increase in tritiated actinomycin binding and in a ratio of the uptake in heterochromatin to that in euchromatin approaching unity.
放线菌素D与染色质中DNA的结合程度取决于染色质的抑制状态。活细胞中，氚标记的放线菌素与常染色质的结合量是与遗传上无活性的异染色质结合量的三倍。组蛋白的提取导致氚标记的放线菌素结合普遍增加，并且异染色质与常染色质的摄取比例接近1。
