Graham C F, Deussen Z A
J Embryol Exp Morphol. 1978 Dec;48:53-72.
The cell lineage of the mouse was studied from the 2-cell stage to the blastocyst. Lineage to the 8-cell stage was followed under the microscope. Each cell from the 2-cell stage divided to form two daughter cells which remained attached. Subsequently, these two daughters each produced two descendants; one of these descendants regularly lay deep in the structure of the embryo while the other was peripheral. Lineage to the blastocyst was followed by injecting oil drops into cells at the 8-cell stage, and then following the segregation of these drops into the inner cell mass and trophectoderm. Between the 8-cell stage and the blastocyst, the deep cells contributed more frequently to the inner cell mass than did the peripheral cells.
从小鼠的2细胞期到囊胚期对其细胞谱系进行了研究。在显微镜下追踪到8细胞期的谱系。2细胞期的每个细胞分裂形成两个仍相连的子细胞。随后，这两个子细胞各自产生两个后代；其中一个后代通常位于胚胎结构的深处，而另一个位于外周。通过在8细胞期向细胞中注入油滴，然后追踪这些油滴向内细胞团和滋养外胚层的分离来追踪到囊胚期的谱系。在8细胞期和囊胚期之间，深层细胞比外周细胞更频繁地向内细胞团贡献。
