Fontana A
Schweiz Med Wochenschr. 1979 Mar 10;109(10):353-8.
Specific chemical signals are recognized by cell receptors which initiate an appropriate biologic response. Autoimmune reactions against hormone receptors can lead to failure of receptor function. Several mechanisms are responsible for either abnormal stimulation or blockade of the receptor-mediated intracellular events. Immunoglobulins which compete with hormone binding to receptors have been found in Graves' disease, in myasthenia gravis, in acanthosis nigricans with insulin resistance, and in a seizure disorder with primary IgA deficiency.
特定的化学信号被细胞受体识别，从而引发适当的生物学反应。针对激素受体的自身免疫反应可导致受体功能失效。有几种机制可导致受体介导的细胞内事件受到异常刺激或阻断。在格雷夫斯病、重症肌无力、伴有胰岛素抵抗的黑棘皮病以及伴有原发性IgA缺乏的癫痫症中，均发现了与激素竞争结合受体的免疫球蛋白。
