Doose H, Völzke E
Neuropadiatrie. 1979 Feb;10(1):10-4. doi: 10.1055/s-0028-1085309.
The course of 117 children with so-called centrencephalic myoclonic-astatic petit mal (Doose et al. 1970) was evaluated with the question, whether petit mal status can be the cause of dementia frequently seen in these patients. A dementia is found definitely more frequently in patients with petit mal status. With regard to the animal experimental studies of Wasterlain (1978, Lit.) and Meldrum (1978, Lit.) it seems possible that the prlonged generalized hypersynchronous discharges of the petit mal status lead to a serious disturbance of the neuronal energy metabolism and thus to cerebral organic damages or disturbances of the brain development.
对117例患有所谓中央脑性肌阵挛 - 无张力性小发作的儿童（Doose等人，1970年）的病程进行了评估，问题是小发作状态是否可能是这些患者中常见痴呆症的病因。在患有小发作状态的患者中，痴呆症的发现确实更为频繁。关于Wasterlain（1978年，文献）和Meldrum（1978年，文献）的动物实验研究，小发作状态下长时间的全身性同步放电似乎有可能导致神经元能量代谢的严重紊乱，进而导致脑器质性损害或脑发育障碍。
