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桥本氏病和局灶性淋巴细胞性甲状腺炎中的细胞浸润。

The cellular infiltrate in Hashimoto's disease and focal lymphocytic thyroiditis.

作者信息

Harris M

出版信息

J Clin Pathol. 1969 May;22(3):326-33. doi: 10.1136/jcp.22.3.326.

DOI:10.1136/jcp.22.3.326
PMID:5819155
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC474076/
Abstract

The lymphoid cells infiltrating the thyroid in three examples of Hashimoto's disease and three examples of focal lymphocytic thyroiditis have been studied by light and electron microscopy. The cell types found were small lymphocytes, plasma cells and plasmablasts, immunoblasts, and cells morphologically intermediate between immunoblasts and small lymphocytes. The infiltrate was similar in the two conditions studied and resembled the cell response found in other conditions thought to be due to delayed hypersensitivity. It is considered that these similarities support the views that focal lymphocytic thyroiditis is a focal form of Hashimoto's disease and that delayed hypersensitivity is important in the pathogenesis of these conditions.

摘要

通过光学显微镜和电子显微镜对3例桥本氏病和3例局灶性淋巴细胞性甲状腺炎患者甲状腺中的淋巴细胞浸润情况进行了研究。发现的细胞类型有小淋巴细胞、浆细胞和成浆细胞、免疫母细胞，以及形态介于免疫母细胞和小淋巴细胞之间的细胞。在所研究的两种病症中，浸润情况相似，类似于在其他被认为由迟发型超敏反应引起的病症中发现的细胞反应。据认为，这些相似之处支持了以下观点：局灶性淋巴细胞性甲状腺炎是桥本氏病的一种局灶形式，迟发型超敏反应在这些病症的发病机制中起重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/496c/474076/d978edb532e7/jclinpath00380-0084-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/496c/474076/b7568328f297/jclinpath00380-0079-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/496c/474076/9d6deb334e64/jclinpath00380-0080-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/496c/474076/e79a2c39958c/jclinpath00380-0081-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/496c/474076/4e6fab6f1b37/jclinpath00380-0082-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/496c/474076/289cf8f0a091/jclinpath00380-0082-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/496c/474076/6d027bcf05a1/jclinpath00380-0083-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/496c/474076/4e39fc8f4dc1/jclinpath00380-0084-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/496c/474076/d978edb532e7/jclinpath00380-0084-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/496c/474076/b7568328f297/jclinpath00380-0079-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/496c/474076/9d6deb334e64/jclinpath00380-0080-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/496c/474076/e79a2c39958c/jclinpath00380-0081-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/496c/474076/4e6fab6f1b37/jclinpath00380-0082-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/496c/474076/289cf8f0a091/jclinpath00380-0082-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/496c/474076/6d027bcf05a1/jclinpath00380-0083-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/496c/474076/4e39fc8f4dc1/jclinpath00380-0084-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/496c/474076/d978edb532e7/jclinpath00380-0084-b.jpg

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