Nickel P, Seidel H R, Preissinger L, Barnickel H, Fink E, Dann O
Arzneimittelforschung. 1978;28(4):578-81.
Ten 2- or 4-amino derivatives 10b-I of 6-(4-diethylamino-1-methylbutylamino)-5,8-dimethoxyquinoline were synthesised with the aim of studying the influence of these substituents on antimalarial activity and toxicity of the 6-aminoquinolines. The 4-dialkylamino derivatives 10c-h were less active against P. vinckei (mouse) than 4-alkoxy derivatives. The 4-amino derivative 10b was inactive.
合成了10种6-(4-二乙氨基-1-甲基丁基氨基)-5,8-二甲氧基喹啉的2-或4-氨基衍生物10b-I，目的是研究这些取代基对6-氨基喹啉抗疟活性和毒性的影响。4-二烷基氨基衍生物10c-h对温氏疟原虫（小鼠）的活性低于4-烷氧基衍生物。4-氨基衍生物10b无活性。
