Pharmacokinetics of amixetrine in the dog. Relation of dose-to-plasma concentration.

N-[(2-Phenyl-2-isoamyloxy)-ethyl-pyrrolidine]-hydrochloride (amixetrine) was administered to dogs at increasing doses, by i.v. and oral routes. Plasma determinations of active principle were carried out by gas liquid chromatography. The sensitivity limits of the method was 0.1 micrograms/ml of plasma. The evolution of the absorption coefficient and variations in half-life as a function of dose, were studied. The results indicate a non-linear, two-compartment open model. A first-pass effect and enzymatic saturation are envisaged.