3-Trifluoromethyl-alpha-ethylbenzhydrol (RGH-3332). Liver enzyme induction and D-glucaric acid excretion.

The enzyme inducing effect of 3-trifluoromethyl-alpha-ethylbenzhydrol (RGH-3332, Zixoryn) has been studied in man by means of determining urinary D-glucaric acid output. RGH-3332 was given for ten days, 300 mg/day to 13, 600 mg/day to 11 and 900 mg/day to 11 patients orally. A significant increase of glucaric acid excretion was found in all three groups confirming the enzyme inducing effect of RGH-3332. A tendency to dose-effect relationship was observed. No signs of adverse drug effects were found by laboratory tests. Minor gastrointestinal side effects were observed in two cases of 35 subjects.