Jönsson N A, Gröningsson K, Pavlu B, Vessman J, Westlund L E
Arzneimittelforschung. 1979;29(2):187-93.
gamma,gamma'-(4,4'-Diamino-3,3'-biphenylylenedioxy)dibutyric acid (dicarboxidine) is a new chromogen developed as a safe substitute for conventional benzidine type reagents. The compound is water soluble and has a low distribution ratio organic phase/aqueous phase, which makes it superior for use with automatic analytical instruments. The stability of both dicarboxidine and its coloured oxidized form are better than and their sensitivity equal to that of o-dianisidine. Dicarboxidine is not mutagenic in Ames test. Studies in mice for two years failed to reveal any carcinogenic activity, studies in rats indicated only a marginal effect.
γ,γ'-（4,4'-二氨基-3,3'-联苯二氧基）二丁酸（二羧联苯胺）是一种新开发的色原，作为传统联苯胺类试剂的安全替代品。该化合物可溶于水，有机相/水相分配比低，这使其在自动分析仪器的使用中具有优势。二羧联苯胺及其有色氧化形式的稳定性均优于邻联茴香胺，且灵敏度与之相当。二羧联苯胺在艾姆斯试验中无致突变性。对小鼠进行的两年研究未发现任何致癌活性，对大鼠的研究仅表明有轻微影响。
