Coltart T M, Beard R W, Turner R C, Oakley N W
Br Med J. 1969 Oct 4;4(5674):17-9. doi: 10.1136/bmj.4.5674.17.
The effects of a maternal intravenous glucose load on the fetal plasma levels of glucose and insulin have been studied in 11 patients before the onset of labour. Within five minutes the fetal plasma glucose concentration rose significantly, indicating a rapid transfer of glucose across the placenta. Following this, the rate of fall in fetal plasma glucose closely reflected that in the mother.Serial fetal insulin estimations carried out in 8 of the 11 subjects following maternal glucose showed an early rise in fetal insulin in four and a delayed rise in one; in the remaining three there was no definite change.It is concluded that the blood glucose level of the fetus is controlled by that of the mother, but that the fetal pancreas at term may respond to hyperglycaemia by the secretion of insulin.
在11名临产前的患者中研究了母体静脉注射葡萄糖负荷对胎儿血浆葡萄糖和胰岛素水平的影响。在5分钟内，胎儿血浆葡萄糖浓度显著升高，表明葡萄糖迅速通过胎盘转运。在此之后，胎儿血浆葡萄糖的下降速率与母体密切相关。在11名受试者中的8名在母体注射葡萄糖后进行的系列胎儿胰岛素测定显示，4名胎儿胰岛素早期升高，1名延迟升高；其余3名没有明显变化。结论是，胎儿的血糖水平受母体控制，但足月时胎儿胰腺可能通过分泌胰岛素对高血糖作出反应。
