静脉注射咪康唑联合鞘内注射两性霉素B治疗播散性球孢子菌病。
Combined intravenous miconazole and intrathecal amphotericin B for treatment of disseminated coccidioidomycosis.
作者信息
Davis S J, Donovan W H
出版信息
Chest. 1979 Aug;76(2):235-6. doi: 10.1378/chest.76.2.235.
A patient received a previously unreported combination of intravenous miconazole and intrathecal amphotericin B for the treatment of disseminated coccidioidomycosis with central nervous system involvement. After first having been treated with amphotericin B, followed by a course of miconazole therapy, the patient responded with remarkable clinical and serologic improvement to the combination of intrathecal amphotericin B and intravenous miconazole. The combination should be considered in the treatment of disseminated coccidioidomycosis with central nervous system involvement.
一名患者接受了静脉注射咪康唑和鞘内注射两性霉素B的联合治疗，此前该联合治疗方案未见报道，用于治疗伴有中枢神经系统受累的播散性球孢子菌病。患者先接受了两性霉素B治疗，随后进行了一个疗程的咪康唑治疗，之后鞘内注射两性霉素B和静脉注射咪康唑联合治疗使患者在临床和血清学方面均有显著改善。对于伴有中枢神经系统受累的播散性球孢子菌病的治疗，应考虑使用该联合治疗方案。
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