Blumenkranz M S, Stevens D A
Arch Ophthalmol. 1980 Jul;98(7):1216-20. doi: 10.1001/archopht.1980.01020040068006.
Three patients with endogenous fungal endophthalmitis were treated intravenously with miconazole. Two patients had disseminated coccidioidomycosis, and one patient had disseminated candidiasis. Intraocular mycotic infections developed in one patient undergoing therapy, and progressed in two others also undergoing therapy. All three patients' ocular infections improved after therapy was switched to intravenous amphotericin B administration. Previous experience with miconazole and amphotericin B therapy for fungal endophthalmitis is reviewed. Whereas several failures have been noted with amphotericin B and success with miconazole, our experience suggests systemic administration of amphotericin B may be superior to systemic administration of miconazole for intraocular mycoses, although further clinical data are urgently needed.
三名患有内源性真菌性眼内炎的患者接受了静脉注射咪康唑治疗。两名患者患有播散性球孢子菌病，一名患者患有播散性念珠菌病。一名正在接受治疗的患者发生了眼内真菌感染，另外两名正在接受治疗的患者感染病情进展。在治疗改为静脉注射两性霉素B后，所有三名患者的眼部感染均有所改善。回顾了先前使用咪康唑和两性霉素B治疗真菌性眼内炎的经验。虽然已注意到两性霉素B治疗有几例失败而咪康唑治疗成功，但我们的经验表明，对于眼内真菌病，两性霉素B全身给药可能优于咪康唑全身给药，不过迫切需要更多临床数据。
