反对在α-糜蛋白酶催化酰胺反应中必然形成酰基酶中间体的证据。 - Suppr | 超能文献

Evidence against the obligatory formation of an acyl enzyme intermediate in the alpha-chymotrypsin catalyzed reactions of amides.

作者信息

Epand R M

出版信息

Biochem Biophys Res Commun. 1969 Oct 8;37(2):313-8. doi: 10.1016/0006-291x(69)90736-0.

DOI:10.1016/0006-291x(69)90736-0

Abstract

摘要

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Evidence against the obligatory formation of an acyl enzyme intermediate in the alpha-chymotrypsin catalyzed reactions of amides.反对在α-糜蛋白酶催化酰胺反应中必然形成酰基酶中间体的证据。

Biochem Biophys Res Commun. 1969 Oct 8;37(2):313-8. doi: 10.1016/0006-291x(69)90736-0.

2

[Kinetics of alpha-chymotrypsin catalyzed hydrolysis in equilibrium. II. Comparison of ester and amide substrates].[α-胰凝乳蛋白酶催化水解反应的动力学平衡。II. 酯和酰胺底物的比较]

Mol Biol (Mosk). 1977 Sep-Oct;11(5):1155-9.

3

Investigations of the chymotrypsin-catalyzed hydrolysis of specific substrates. V. Determination of pre-steady state kinetic parameters for specific substrate esters by stopped flow techniques.胰凝乳蛋白酶催化特定底物水解的研究。V. 用停流技术测定特定底物酯的稳态前动力学参数。

J Biol Chem. 1971 May 10;246(9):2918-25.

4

Kinetics of the alpha-chymotrypsin-catalyzed hydrolysis of N-ACETYL-L-phenylalanylglycine amide in the equilibrium state: profit of an acylenzyme mechanism.α-胰凝乳蛋白酶催化N-乙酰-L-苯丙氨酰甘氨酸酰胺在平衡状态下水解的动力学：酰基酶机制的作用

Mol Biol. 1974 May;7(6):667-72.

5

On the elucidation of the pH dependence of chymotrypsin catalyzed reactions at alkaline pH.关于胰凝乳蛋白酶在碱性pH条件下催化反应的pH依赖性的阐明。

Biochem Biophys Res Commun. 1966 May 3;23(3):234-9. doi: 10.1016/0006-291x(66)90533-x.

6

[Adjustment of the substrate as rate-determining step in the enzymatic cleavage of esters and amides by chymotrypsin A].[通过胰凝乳蛋白酶A对酯和酰胺进行酶促裂解时作为速率决定步骤的底物调整]

Hoppe Seylers Z Physiol Chem. 1969 Dec;350(12):1501-12.

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Separation of polar, steric and specific effects in the alpha-chymotrypsin-catalyzed hydrolysis of acyl-substituted p-nitrophenyl esters.α-胰凝乳蛋白酶催化酰基取代对硝基苯酯水解过程中极性、空间效应和特异性效应的分离

Biochem Biophys Res Commun. 1970 Oct 23;41(2):464-70. doi: 10.1016/0006-291x(70)90528-0.

8

Demonstration of a change in the rate-determining step in papain- and ficin-catalyzed acyl-transfer reactions.木瓜蛋白酶和无花果蛋白酶催化的酰基转移反应中速率决定步骤变化的证明。

Biochemistry. 1971 Jul 6;10(14):2717-26. doi: 10.1021/bi00790a010.

9

Acylation of chymotrypsin by active esters of nonspecific substrates. Evidence for a transient acylimidazole intermediate.非特异性底物活性酯对胰凝乳蛋白酶的酰化作用。关于瞬时酰基咪唑中间体的证据。

Biochemistry. 1972 Jun 20;11(13):2483-93. doi: 10.1021/bi00763a016.

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Water soluble polycationic derivatives of trypsin and chymotrypsin--preparation and properties.胰蛋白酶和糜蛋白酶的水溶性聚阳离子衍生物——制备与性质

Biochem Biophys Res Commun. 1972 Mar 24;46(6):2054-61. doi: 10.1016/0006-291x(72)90758-9.

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Purification of Bacteroides amylophilus protease.嗜淀粉拟杆菌蛋白酶的纯化

J Bacteriol. 1971 May;106(2):394-402. doi: 10.1128/jb.106.2.394-402.1971.

2

alpha-Chymotrypsin as the catalyst for peptide synthesis.α-胰凝乳蛋白酶作为肽合成的催化剂。

Biochem J. 1977 Jun 1;163(3):531-42. doi: 10.1042/bj1630531.