毒扁豆碱对由左啡诺（一种吗啡同系物）引起的小鼠“奔跑发作”的拮抗作用。
Antagonism by physostigmine of the "running fit" caused by levorphanol, a morphine congener, in mice.
作者信息
Sharkawi M, Goldstein A
出版信息
Br J Pharmacol. 1969 Sep;37(1):123-8. doi: 10.1111/j.1476-5381.1969.tb09529.x.
Abstract
- Drugs of the morphine type cause a stereotyped "running fit" in the mouse.2. The intensity and duration of this response are related to the dose.3. Measurement of this phenomenon serves as a good method for the quantitative comparison of drugs of this type and for the study of their antagonists.4. Intracerebral injection of physostigmine antagonized the "running fit" induced by a wide range of doses of levorphanol.5. The results are consistent with the hypothesis that drugs of the morphine type act by retarding the release of acetylcholine at some central cholinergic synapses.
摘要
吗啡类药物可使小鼠产生一种刻板的“奔跑发作”。
这种反应的强度和持续时间与剂量有关。
对这一现象的测量是对这类药物进行定量比较及其拮抗剂研究的良好方法。
脑内注射毒扁豆碱可拮抗多种剂量左啡诺引起的“奔跑发作”。
这些结果与吗啡类药物通过抑制某些中枢胆碱能突触处乙酰胆碱的释放而起作用的假说相符。
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本文引用的文献
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The effect of cortisone, desoxycorticosterone, and adrenocorticotrophic hormone upon the responses of animals to analgesic drugs.可的松、脱氧皮质酮及促肾上腺皮质激素对动物对镇痛药反应的影响。
J Pharmacol Exp Ther. 1951 Sep;103(1):93-105.
3
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J Physiol. 1965 Apr;177(3):411-9. doi: 10.1113/jphysiol.1965.sp007600.
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