Fleischhauer J
Arzneimittelforschung. 1978;28(9):1491-2.
Two identical groups of schizophrenic patients were treated for 28 days randomized with 3 and 8 mg of pimozide. In the antipsychotic efficacy no difference could be seen. Difference was in side effects: The 8-mg group had three times more extrapyramidal signs, mostly akathisia and agitation, and needed seven times more minor tranquilizer than the 3-mg group. Severe agitation as a psychotic symptom was equal in both groups. Preference therefore is given to the smaller dosage.
两组相同的精神分裂症患者被随机分为两组，分别接受28天的3毫克和8毫克匹莫齐特治疗。在抗精神病疗效方面未见差异。差异在于副作用：8毫克组的锥体外系症状是3毫克组的三倍，主要是静坐不能和激动，且使用的小剂量镇静剂是3毫克组的七倍。两组中作为精神病症状的严重激动程度相同。因此，更倾向于较小剂量。
