[喹哌嗪拮抗巴氯芬活性。巴氯芬和γ-羟基丁酸对大鼠脑内5-羟色胺代谢的影响（作者译）]
[Quipazine antagonizing baclofen activity. Influence of baclofen and gamma-hydroxybutyric acid on serotonin metabolism in rat brain (author's transl)].
作者信息
Waldmeier P C, Maître L
出版信息
Arzneimittelforschung. 1978;28(9):1507-8.
PMID:582544
Abstract
Baclofen increases the concentration of serotonin (5-HT) and 5-hydroxyindolacetic acid (5-HIAA) in the rat c. striatum without causing concomitant increase in 5-HT biosynthesis. The effect of baclofen on 5-HIAA, but not that on 5-HT, was antagonized dose-dependently by quipazine. It is assumed that quipazine acts by stimulating 5-HT autoreceptors.
摘要
巴氯芬可增加大鼠尾状核中血清素（5-羟色胺，5-HT）和5-羟吲哚乙酸（5-HIAA）的浓度，而不会同时引起5-HT生物合成增加。喹哌嗪可剂量依赖性地拮抗巴氯芬对5-HIAA的作用，但对5-HT无此作用。据推测，喹哌嗪通过刺激5-HT自身受体发挥作用。
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