Delini-Stula A, Vassout A
Arzneimittelforschung. 1978;28(9):1508-9.
Effects of baclofen, 5-aminomethyl-3-hydroxyisoxazol (muscimol) and GABA-cetylester on spontaneous and olfactory bulb-ablation-induced muricidal behaviour in rats was investigated. At doses of 3--10 mg/kg i.p. baclofen inhibited the killer reaction in spontaneous and lesioned rats to the same extent. In contrast, muscimol (0.75--1.5 mg/kg i.p.) and GABA-cetylester (10--50mg/kg i.p.) depressed markedly only the spontaneous muricidal response. These findings suggest a possibility that muscimol and GABA-cetylester exert their inhibitory action through an activation of GABA-neurons localized in the bulbus olfactorius, whereas baclofen appears to affect also neuronal systems outside this nervous structure.
研究了巴氯芬、5-氨基甲基-3-羟基异恶唑（蝇蕈醇）和γ-氨基丁酸乙酯对大鼠自发及嗅球切除诱导的杀鼠行为的影响。腹腔注射剂量为3-10mg/kg时，巴氯芬对自发及损伤大鼠的杀伤反应具有同等程度的抑制作用。相比之下，蝇蕈醇（腹腔注射0.75-1.5mg/kg）和γ-氨基丁酸乙酯（腹腔注射10-50mg/kg）仅显著抑制自发杀鼠反应。这些发现提示，蝇蕈醇和γ-氨基丁酸乙酯可能通过激活位于嗅球的γ-氨基丁酸能神经元发挥抑制作用，而巴氯芬似乎也会影响该神经结构之外的神经元系统。
