Steffen R
Arzneimittelforschung. 1979;29(4):685-8.
The pharmacological properties of difenoxin hydrochloride, a meperidine derivative exerting antidiarrheal effect, are presented. The drug is compared with related substances such as diphenoxylate hydrochloride and loperamide. In an open multicentre study including 259 patients with acute or chronic diarrhea of various etiology, difenoxin hydrochloride removed the complaints in 63--75% of the cases and improved them in some further 20%. Mild side effects were seen in 4% of the cases. In view of the necessity to obtain immediate therapeutic results such an antidiarrheal may be prescribed in cases of traveler's diarrhea despite certain doubts. However, the patients should be warned to see a doctor if certain symptoms appeared.
介绍了具有止泻作用的哌替啶衍生物盐酸地芬诺酯的药理特性。将该药物与相关物质如盐酸地芬诺酯和洛哌丁胺进行了比较。在一项包括259例各种病因的急性或慢性腹泻患者的开放性多中心研究中，盐酸地芬诺酯在63%-75%的病例中消除了症状，另有约20%的病例症状得到改善。4%的病例出现轻微副作用。鉴于需要立即获得治疗效果，尽管存在某些疑虑，但在旅行者腹泻的情况下仍可开具这种止泻药。然而，应警告患者如果出现某些症状要去看医生。
