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[磷酸化乙酰胆碱酯酶的重新激活。吡啶肟的异构双季铵盐]

[Reactivation of phosphorylated acetylcholinesterase. Isomeric bisquaternary salts of pyridine aldoximes].

作者信息

Hagedorn I, Stark I, Schoene K, Schenkel H

出版信息

Arzneimittelforschung. 1978;28(11):2055-7.

PMID:582905
Abstract

Mono-quaternary salts Z have been prepared from pyridine-aldoximes and 1,3-dihalogen compounds. These were used to synthesize asymmetrical bis-quaternary pyridine-oximes with three-membered bridge. The effect of reactivation of phosphorylated AChE by these substances is less than that of obidoxim (Toxogonin).

摘要

单季铵盐Z是由吡啶醛肟和1,3 - 二卤化合物制备而成。这些化合物被用于合成具有三元桥的不对称双季铵吡啶肟。这些物质对磷酸化乙酰胆碱酯酶的重新激活作用小于双复磷（双复磷）。

相似文献

1
[Reactivation of phosphorylated acetylcholinesterase. Isomeric bisquaternary salts of pyridine aldoximes].[磷酸化乙酰胆碱酯酶的重新激活。吡啶肟的异构双季铵盐]
Arzneimittelforschung. 1978;28(11):2055-7.
2
[Betaines of quaternary salts of pyridine-2-and -4-aldoxim (author's transl)].
Arzneimittelforschung. 1976;26(5):753-5.
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Potential acetylcholinesterase reactivators: pyridine and alpha-oxooxime derivatives.潜在的乙酰胆碱酯酶复活剂：吡啶和α-氧代肟衍生物。
Pharmazie. 1986 Oct;41(10):699-702.
4
[Reactivation of phosphorylated acetylcholinesterase (AChE): quaternary salts of vinylogous pyridinaldoxims (author's transl)].[磷酸化乙酰胆碱酯酶（AChE）的再激活：乙烯基吡啶醛肟的季铵盐（作者译）]
Arzneimittelforschung. 1976;26(8):1515-7.
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Reactivation of isopropyl-methylphosphonylated bovine erythrocyte acetylcholinesterase by quaternary pyridine-2-aldoximes.季铵盐吡啶 - 2 - 醛肟对异丙基 - 甲基膦酰化牛红细胞乙酰胆碱酯酶的重新激活作用
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Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro.几种肟类化合物在体外对被对氧磷抑制的人乙酰胆碱酯酶和丁酰胆碱酯酶的重活化能力。
Chem Biol Interact. 2008 Sep 25;175(1-3):421-4. doi: 10.1016/j.cbi.2008.05.004. Epub 2008 May 7.
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Reactivation and aging kinetics of human acetylcholinesterase inhibited by organophosphonylcholines.有机磷酰胆碱抑制的人乙酰胆碱酯酶的复活和老化动力学
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[In vitro reactivation of acetylcholinesterase inhibition by O-isopropylmethylfluorophosphonate using the bisquarternary oxime, HS-6].[使用双季铵肟HS-6对O-异丙基甲基氟磷酸酯抑制乙酰胆碱酯酶的体外重新激活作用]
Ceska Slov Farm. 2004 Mar;53(2):93-5.
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[THE INTERRELATION OF CHEMICAL STRUCTURE AND CHOLINESTERASE REACTIVATING EFFECT IN A SERIES OF NEW BIS-QUATERNARY PYRIDINE-4-ALDOXIMES].[一系列新型双季铵吡啶 -4-醛肟的化学结构与胆碱酯酶复活作用的相互关系]
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Cholinesterase reactivation in vivo with a novel bis-oxime optimized by computer-aided design.
J Pharmacol Exp Ther. 2003 Oct;307(1):190-6. doi: 10.1124/jpet.103.053405. Epub 2003 Jul 31.

引用本文的文献

1
Bisquaternary pyridinium oximes: Comparison of in vitro reactivation potency of compounds bearing aliphatic linkers and heteroaromatic linkers for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase.双季铵吡啶𬭩肟：比较含脂肪族连接基和杂芳环连接基的化合物对马拉硫磷抑制的电鳗和重组人乙酰胆碱酯酶的体外重活化效力。
Bioorg Med Chem. 2010 Jan 15;18(2):787-94. doi: 10.1016/j.bmc.2009.11.052. Epub 2009 Nov 27.
2
Reactivators of organophosphate-inhibited cholinesterase. Phenylhydroxymethyl and cyclohexylhydroxymethyl substituted bis-pyridinium monooximes.
Arch Toxicol. 1982 Mar;49(3-4):285-91. doi: 10.1007/BF00347876.
3
Reactivators of organophosphate-inhibited cholinesterase. 4-cycloalkylcarbonyl substituted bis-pyridinium monooximes.
Arch Toxicol. 1984 Sep;55(3):199-202. doi: 10.1007/BF00316129.
4
HLö 7 dimethanesulfonate, a potent bispyridinium-dioxime against anticholinesterases.HLö 7二甲磺酸盐，一种强效的双吡啶二肟类抗胆碱酯酶药物。
Arch Toxicol. 1992;66(9):603-21. doi: 10.1007/BF01981499.