[磷酸化乙酰胆碱酯酶的重新激活。吡啶肟的异构双季铵盐]
[Reactivation of phosphorylated acetylcholinesterase. Isomeric bisquaternary salts of pyridine aldoximes].
作者信息
Hagedorn I, Stark I, Schoene K, Schenkel H
出版信息
Arzneimittelforschung. 1978;28(11):2055-7.
PMID:582905
Abstract
Mono-quaternary salts Z have been prepared from pyridine-aldoximes and 1,3-dihalogen compounds. These were used to synthesize asymmetrical bis-quaternary pyridine-oximes with three-membered bridge. The effect of reactivation of phosphorylated AChE by these substances is less than that of obidoxim (Toxogonin).
摘要
单季铵盐Z是由吡啶醛肟和1,3 - 二卤化合物制备而成。这些化合物被用于合成具有三元桥的不对称双季铵吡啶肟。这些物质对磷酸化乙酰胆碱酯酶的重新激活作用小于双复磷（双复磷）。
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