5-([2-(二乙氨基)-乙基]氨基)-3-苯基-1,2,4-恶二唑二盐酸盐（DEPO）对犬心脏功能和心肌代谢的影响
Effects of 5-([2-(diethylamino)-ethyl]amino)-3-phenyl-1,2,4-oxadiazole dihydrochloride (DEPO) on cardiac functions and myocardial metabolism of the dog.
作者信息
Sakanashi M, Araki H, Sakai K, Mizusawa H
出版信息
Arzneimittelforschung. 1978;28(11):2076-9.
Effects of 5-([2-(diethylamino)-ethyl]amino)-3-phenyl-1,2,4-oxadiazole (DEPO) on cardiac functions and myocardial metabolism were examined using the heart in vivo and the isolated perfused heart of dogs. In the heart in vivo DEPO i.v. produced dose-dependent decreases in coronary perfusion pressure (PP), heart rate (HR), left ventricular pressure (LVP), dP/dt max of LVP and coronary vascular resistance (VR). DEPO i.c. dose-dependently increased left circumflex coronary flow (LCCF) and decreased PP, LVP and dP/dt max of LVP, but did not change HR. In the isolated perfused heart, DEPO induced a marked increase in coronary blood flow (CBF) and depressed HR and myocardial contractile force. Myocardial oxygen consumption and myocardial redox potential were not significantly changed. DEPO could not modify the effects of isoproterenol, adenosine and reactive hyperaemia on the heart. The results suggest that DEPO may have a coronary vasodilating action and some direct inhibitory actions on the heart.
利用犬的在体心脏和离体灌注心脏，研究了5-([2-(二乙氨基)-乙基]氨基)-3-苯基-1,2,4-恶二唑（DEPO）对心脏功能和心肌代谢的影响。在犬的在体心脏中，静脉注射DEPO可使冠状动脉灌注压（PP）、心率（HR）、左心室压力（LVP）、LVP的dP/dt max以及冠状动脉血管阻力（VR）呈剂量依赖性降低。冠状动脉内注射DEPO可使左旋冠状动脉血流量（LCCF）剂量依赖性增加，并使PP、LVP和LVP的dP/dt max降低，但不改变HR。在离体灌注心脏中，DEPO可使冠状动脉血流量（CBF）显著增加，并使HR和心肌收缩力降低。心肌耗氧量和心肌氧化还原电位无明显变化。DEPO不能改变异丙肾上腺素、腺苷和反应性充血对心脏的作用。结果表明，DEPO可能具有冠状动脉舒张作用以及对心脏的一些直接抑制作用。
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