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非班太尔,一种新型广谱驱虫药。

Febantel, a new broad-spectrum anthelminthic.

作者信息

Wollweber H, Kölling H, Widdig A, Thomas H, Schulz H P, Mürmann P

出版信息

Arzneimittelforschung. 1978;28(12):2193-5.

PMID:582930
Abstract

N-(2-[2,3-Bis-(methoxycarbonyl)-guanidino]-5-(phenylthio)-phenyl)-2-methoxyacetamide (febantel, Rintal) is a new compound which is highly active against various species of nematodes and cestodes in mice, rats, dogs, sheep and cattle. In sheep and cattle a single oral dose of 5 mg/kg resulted in an almost complete elimination of larval and adult intestinal nematodes as well as Dictyocaulus. The compound was well tolerated by all animals tested.

摘要

N-(2-[2,3-双(甲氧基羰基)-胍基]-5-(苯硫基)-苯基)-2-甲氧基乙酰胺(非班太尔,Rintal)是一种新化合物,对小鼠、大鼠、狗、绵羊和牛体内的各种线虫和绦虫具有高度活性。在绵羊和牛中,单次口服剂量为5毫克/千克,几乎能完全消除幼虫和成虫阶段的肠道线虫以及网尾线虫。所有受试动物对该化合物耐受性良好。

相似文献

1
Febantel, a new broad-spectrum anthelminthic.非班太尔,一种新型广谱驱虫药。
Arzneimittelforschung. 1978;28(12):2193-5.
2
Amidantel, a potent anthelminthic from a new chemical class.
Arzneimittelforschung. 1979;29(1):31-2.
3
The efficacy of febantel on gastrointestinal nematodes in sheep.
Res Vet Sci. 1978 Nov;25(3):290-3.
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[2-(Guanidino)-anilides and related compounds. Synthesis and anthelmintic effect. 3. Anthelmintics].[2-(胍基)-苯胺类及相关化合物。合成与驱虫作用。3. 驱虫药]
Arzneimittelforschung. 1984;34(5):531-42.
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Activity of febantel on natural infections of gastrointestinal helminths in lambs in a controlled test.
Am J Vet Res. 1988 Jun;49(6):901-2.
6
Efficacy of a drug combination of praziquantel, pyrantel embonate, and febantel against helminth infections in dogs.吡喹酮、双羟萘酸噻嘧啶和非班太尔药物组合对犬类蠕虫感染的疗效。
Am J Vet Res. 1992 Dec;53(12):2272-3.
7
[Usefulness of febantel for the inhibition of the "spring rise" phenomenon in sheep].
Wiad Parazytol. 1984;30(4):483-7.
8
A re-assessment of the efficacy of febantel (Rintal) and fenbendazole (Panacur) against Strongyloides papillosus in sheep and goats.对非班太尔(Rintal)和芬苯达唑(Panacur)治疗绵羊和山羊乳头类圆线虫效果的重新评估。
J S Afr Vet Assoc. 1980 Mar;51(1):49-50.
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The efficacy of amidantel, a new anthelmintic, on hookworms and ascarids in dogs.
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[Metabolism-embryotoxicity relationship of febantel in the rat and the sheep].
Ann Rech Vet. 1982;13(2):163-70.

引用本文的文献

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Methyl N-({[2-(2-meth-oxy-acetamido)-4-(phenyl-sulfan-yl)phen-yl]amino}[(meth-oxy-carbonyl)imino]methyl)carbamate.N-({[2-(2-甲氧基-乙酰氨基)-4-(苯硫基)苯基]氨基}[(甲氧基羰基)亚氨基]甲基)氨基甲酸甲酯
Acta Crystallogr Sect E Struct Rep Online. 2012 Mar 1;68(Pt 3):o581-2. doi: 10.1107/S1600536812002760. Epub 2012 Feb 4.
2
Antiparasitic agents. 4. Injectable phenylguanidine anthelmintics.
Experientia. 1980 Dec 15;36(12):1389-90. doi: 10.1007/BF01960114.