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Influence of cicloxilic acid on energy production by hepatocyte mitochondria during acute ethanol intoxication.

作者信息

Cottalasso D, Gambella G R, Pronzato M A, Averame M M, Nanni G, Marinari U M

出版信息

Arzneimittelforschung. 1978;28(7a):1224-6.

PMID:582960
Abstract

Liver mitochondria from acute ethanol intoxicated rats show a highly significant uncoupling of oxidative phosphorylation. cis-2-Hydroxy-2-phenyl-cyclohexanecarboxylic acid (cicloxilic acid) early normalizes the P/O ratio and, therefore, the mitochondrial energy producing mechanisms. The significance of these phenomena and the possible role of cicloxilic acid on mitochondrial energy-production are discussed.

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