Wendt H, Kessler J
Arzneimittelforschung. 1979;29(5):846-8.
A comparative study (occlusion test according to Marples and Kligman) was conducted in 100 test subjects with several formulations of isoconazole nitrate. The following results were obtained: 1. There are no differences in efficacy between the free base, isoconazole, and the nitrate. 2. Increasing the active substance concentration of isoconazole nitrate above 1% produced a noticeable increase in its effect so that 2% and 4% preparations are appropriate for particular uses. 3. 1% isoconazole nitrate (Travogen cream, Gyno-Travogen cream) is more effective than a commercial cream containing 1% clotrimazole. 4. The addition of a corticosteroid (diflucortolone-21-valerate 0.1%, Travocort cream) does not influence the action of isoconazole nitrate.
对100名受试者使用几种硝酸异康唑制剂进行了一项对比研究（根据马普尔斯和克利格曼的封闭试验）。得到以下结果：1. 游离碱、异康唑和硝酸盐在疗效上没有差异。2. 将硝酸异康唑的活性物质浓度提高到1%以上会使其效果显著增加，因此2%和4%的制剂适用于特定用途。3. 1%硝酸异康唑（曲沃净乳膏、妇科曲沃净乳膏）比含1%克霉唑的市售乳膏更有效。4. 添加皮质类固醇（21-戊酸地夫可特0.1%，曲沃可特乳膏）不会影响硝酸异康唑的作用。
