[4-氯苯氧异丁酸镁（Mg-CPIB）对大鼠肝脏过氧化物酶体中脂肪酸氧化的诱导作用]
[Induction of fatty acid oxidation in peroxisomes of rat liver by magnesium-4 chlorophenoxyisobutyrate (Mg-CPIB)].
作者信息
Paltauf F, Magnet K
出版信息
Arzneimittelforschung. 1979;29(8):1132-4.
Magnesium-4-chlorophenoxyisobutyrate (Mg-CPIB) and ethyl-CPIB were administered to adult male rats. After one and two weeks, respectively, the peroxysomal fraction from the livers was isolated and activities of fatty acid beta-oxidation and catalase were measured. With both drugs, catalase activity was only slightly induced (50%), whereas a great increase of fatty acid oxidizing enzymes was observed. After both time intervals the inducing effect of the magnesium salt of CPIB was significantly higher than that of the ethyl ester. The bearing of the induction of peroxysomal fatty acid oxidation on the hypolipidemic effect of CPIB is discussed.
将4-氯苯氧异丁酸镁（Mg-CPIB）和4-氯苯氧异丁酸乙酯（ethyl-CPIB）给予成年雄性大鼠。分别在1周和2周后，分离肝脏中的过氧化物酶体部分，并测定脂肪酸β-氧化和过氧化氢酶的活性。使用这两种药物时，过氧化氢酶活性仅略有诱导（50%），而脂肪酸氧化酶则显著增加。在两个时间间隔后，CPIB镁盐的诱导作用均显著高于乙酯。本文讨论了过氧化物酶体脂肪酸氧化的诱导对CPIB降血脂作用的影响。
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