Vormittag W, Kolarz G
Arzneimittelforschung. 1979;29(8):1163-8.
Studies on chromosomes of lymphocyte cultures of peripheral blood were performed in 15 patients with rheumatoid arthritis (group I: 48-h culture, n = 8; group II; 72-h culture, n = 7) before and after phenylbutazone infusion therapy (600 mg/d for 10 days). The average rate of cells with exchange aberrations of chromosomal type after this therapy (group I: 0.52%; group II: 0.69%) was higher than the control values found before treatment (group I: 0.13%; group II: 0%); X2 test: group I + II: P less than 0.025. The results obtained are discussed.
对15例类风湿性关节炎患者（第一组：48小时培养，n = 8；第二组：72小时培养，n = 7）在使用保泰松输注疗法（600毫克/天，共10天）前后进行了外周血淋巴细胞培养染色体研究。该疗法后染色体类型交换畸变细胞的平均发生率（第一组：0.52%；第二组：0.69%）高于治疗前的对照值（第一组：0.13%；第二组：0%）；卡方检验：第一组+第二组：P小于0.025。对所得结果进行了讨论。
