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双嘧达莫在孕期血池动力学作用的研究(作者译)

[Studies of the blood pool dynamic actions of dipyridamole in pregnancy (author's transl)].

作者信息

Lippert T H, Cloeren S E, Fridrich R

出版信息

Arzneimittelforschung. 1979;29(8):1172-4.

PMID:583018
Abstract

The action of 2,6-bis(diethanolamino)-4,8-dipiperidinopyrimido-(5,4-d)pyrimidine (dipyridamole, Persantin) on utero-placental and cardiac blood pool dynamics was examined in 12 pregnant women. 113mIndium was injected i.v. and blood pool changes in the heart, placenta and myometrium were registered by external measurement of the gamma-activity. While there was a significant decrease in blood pool of the heart after dipyridamole, there were no marked changes in the blood pools of placenta or myometrium. The decrease in cardiac blood pool was interpreted as a sign of an increase in the cardiac output.

摘要

在12名孕妇中研究了2,6 - 双(二乙醇氨基)- 4,8 - 二哌啶基嘧啶并(5,4 - d)嘧啶(双嘧达莫,潘生丁)对子宫 - 胎盘和心脏血池动力学的作用。静脉注射113m铟,通过外部测量γ活性记录心脏、胎盘和子宫肌层的血池变化。双嘧达莫给药后心脏血池显著减少,而胎盘和子宫肌层的血池无明显变化。心脏血池减少被解释为心输出量增加的迹象。

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