Darvas F, Mészáros Z, Kovács L, Hermecz I, Balogh M, Kardos J
Arzneimittelforschung. 1979;29(9):1334-9.
On the basis of 576 in vitro antibacterial positive results of 99 compounds containing gamma-pyridone-beta-carboxylic acid structure conclusions have been drawn on the mechanism of action of the derivatives by principal component analysis. It has been found that the compounds exert their effect essentially by influencing two types of physiological processes or series of processes. The more important of the two "mechanisms", responsible for 50-95% of the activity of the compounds, is common for the compounds investigated, and is associated with the gamma-pyridone-beta-carboxylic acid structure.
基于99种含有γ-吡啶酮-β-羧酸结构的化合物的576个体外抗菌阳性结果，通过主成分分析得出了这些衍生物的作用机制结论。已发现这些化合物主要通过影响两种生理过程或一系列过程来发挥作用。这两种“机制”中更重要的一种，负责化合物50% - 95%的活性，是所研究化合物共有的，并且与γ-吡啶酮-β-羧酸结构相关。
