de Estable-Puig R F, Estable-Puig J F, Vincent O, Defféminis H A, Médici M
Acta Neurol Latinoam. 1979;25(1-2):1-26.
Basic changes of the striated muscle fiber are described after the electron microscopy study of 200 surgical muscle biopsies from the Montevideo Neurological Institute. The inventory of these changes--true ultrastructural "signs" of muscle derangement--is presented according to the involved organelle. The value of these data is considerably enhanced by a systematic approach to the study of a muscle biopsy that should begin with the in situ examination of the muscle territory before the excision of the tissue. A throroughful histopathological study and a careful screening of semithin sections previous to the selection of areas for E.M. are also of paramount importance. The description of individual fiber lesions and that of the topography of the lesions should be accompanied by the study of vessels. nerves and muscle spindles. We stress that most of the ultrastructural findings are nonspecific. They will however acquire diagnostic value and greater interest when grouped and related to the clinical data and to the results of other diagnostic methods, besides morphology.
通过对蒙得维的亚神经学研究所200份手术肌肉活检样本进行电子显微镜研究，描述了横纹肌纤维的基本变化。根据受累细胞器，列出了这些变化——肌肉紊乱的真正超微结构“体征”。通过系统研究肌肉活检来极大提高这些数据的价值，该研究应在组织切除前对肌肉区域进行原位检查。在选择用于电子显微镜检查的区域之前，进行全面的组织病理学研究和仔细筛选半薄切片也至关重要。对单个纤维病变的描述以及病变的地形图描述应伴有对血管、神经和肌梭的研究。我们强调，大多数超微结构发现是非特异性的。然而，当将它们分组并与临床数据以及除形态学之外的其他诊断方法的结果相关联时，它们将具有诊断价值并更具意义。
