19-羟基前列腺素E与男性不育症

19-Hydroxy-prostaglandin E and infertility in human males.

作者信息

Lewy R I, Bills T K, Dalton J, Smith J B, Silver M J

出版信息

Prostaglandins Med. 1979 May;2(5):367-72. doi: 10.1016/0161-4630(79)90109-5.

Abstract

We measured the content of 19-hydroxy-prostaglandin E (19-OH-PGE) and prostaglandin E (PGE) in the semen of 10 infertile males by alkaline dehydration, thin layer chromatographic separation and ultraviolet spectrophotometry. 7 fertile males were also studied. In both groups the content of seminal 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) also was measured by thin layer chromatographic separation and highly specific radioimmunoassay. The amounts of 19-OH-PGE and PGE were significantly lower (p < .02, p < .05) in the infertile group than the fertile group. Differences in mean seminal 6-keto-F1 alpha were not significant. The uterine stimulatory actions of 19-OH-PGE demonstrable in the monkey may apply to fertility in man.

摘要

我们采用碱脱水、薄层色谱分离及紫外分光光度法，测定了10名不育男性精液中19-羟基前列腺素E（19-OH-PGE）和前列腺素E（PGE）的含量。同时也对7名生育能力正常的男性进行了研究。两组均采用薄层色谱分离及高特异性放射免疫分析法测定精液中6-酮-前列腺素F1α（6-酮-PGF1α）的含量。不育组的19-OH-PGE和PGE含量显著低于生育能力正常组（p < 0.02，p < 0.05）。精液中6-酮-F1α的平均差异不显著。在猴子身上证实的19-OH-PGE对子宫的刺激作用可能适用于人类生育。