Asymmetrical incorporation of amino acids in the alpha and beta chains of hemoglobin synthesized by thalassemic reticulocytes.
作者信息
Heywood D, Karon M, Weissman S
出版信息
J Lab Clin Med. 1965 Sep;66(3):476-82.
PMID:5835972
Abstract
摘要
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Isolation and translation of hemoglobin messenger RNA from thalassemia, sickle cell anemia, and normal human reticulocytes.从地中海贫血、镰状细胞贫血和正常人网织红细胞中分离和翻译血红蛋白信使核糖核酸。
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Cell-free hemoglobin synthesis in beta-thalassemia.β地中海贫血中的无细胞血红蛋白合成
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Unbalanced globin chain synthesis in reticulocytes of sickle cell trait individuals with low concentrations of hemoglobin S.血红蛋白S浓度较低的镰状细胞性状个体网织红细胞中珠蛋白链合成不平衡。
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Delayed removal of N-terminal methionine from nascent globin chains in sickle-cell anemia reticulocytes.镰状细胞贫血网织红细胞中新生珠蛋白链N端甲硫氨酸的去除延迟。
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Studies on the quantitative control of polypeptide synthesis in human reticulocytes.人类网织红细胞中多肽合成的定量控制研究。
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Effects of thyroxine on initiation and completion of protein chains of hemoglobin in vitro.
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Studies of the kinetics of alpha and beta hemoglobin chain synthesis.
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引用本文的文献
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Hemoglobin synthesis in beta-thalassemia: the properties of the free alpha-chains.β地中海贫血中的血红蛋白合成：游离α链的特性
J Clin Invest. 1968 Apr;47(4):860-6. doi: 10.1172/JCI105779.
2
Rate of synthesis of haemoglobin A2 in thalassaemia.地中海贫血中血红蛋白A2的合成速率
Z Kinderheilkd. 1971;109(4):271-8. doi: 10.1007/BF00438970.
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Cell-free hemoglobin synthesis in beta-thalassemia.β地中海贫血中的无细胞血红蛋白合成
Proc Natl Acad Sci U S A. 1970 Dec;67(4):1854-61. doi: 10.1073/pnas.67.4.1854.
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Defect in messenger RNA for human hemoglobin synthesis in beta thalassemia.β地中海贫血中人类血红蛋白合成信使核糖核酸的缺陷。
J Clin Invest. 1971 Dec;50(12):2755-60. doi: 10.1172/JCI106778.
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Translation of -globin m-RNA in -thalassemia and the S and C hemoglobinopathies.β-地中海贫血以及血红蛋白S病和血红蛋白C病中β-珠蛋白信使核糖核酸的翻译
J Clin Invest. 1972 Feb;51(2):364-72. doi: 10.1172/JCI106822.
6
Decreased globin messenger RNA in thalassemia detected by molecular hybridization.通过分子杂交检测到地中海贫血中珠蛋白信使核糖核酸减少。
Proc Natl Acad Sci U S A. 1973 Jun;70(6):1886-90. doi: 10.1073/pnas.70.6.1886.
7
Quantitative deficiency of chain-specific globin messenger ribonucleic acids in the thalassemia syndromes.地中海贫血综合征中链特异性珠蛋白信使核糖核酸的定量缺乏。
Proc Natl Acad Sci U S A. 1973 Jun;70(6):1809-13. doi: 10.1073/pnas.70.6.1809.
8
Further evidence of a quantitative deficiency of chain-specific globin mRNA in the thalassemia syndromes.地中海贫血综合征中特定链珠蛋白mRNA定量缺乏的进一步证据。
Proc Natl Acad Sci U S A. 1975 Feb;72(2):567-71. doi: 10.1073/pnas.72.2.567.
9
Globin chain synthesis in sickle beta-thalassaemic bone marrow and reticulocytes.镰状β地中海贫血骨髓和网织红细胞中的珠蛋白链合成
J Med Genet. 1979 Aug;16(4):296-301. doi: 10.1136/jmg.16.4.296.
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