三叉神经痛的病理生理学

Pathophysiology of trigeminal neuralgia.

作者信息

Loeser J D, Calvin W H, Howe J F

出版信息

Clin Neurosurg. 1977;24:527-37. doi: 10.1093/neurosurgery/24.cn_suppl_1.527.

DOI:10.1093/neurosurgery/24.cn_suppl_1.527

Abstract

Tic douloureux is a painful affliction of man without known similarities to diseases in infrahuman species or to other human afflictions. It seems to be associated with structural abnormalities encroaching upon the trigeminal nerve, gasserian ganglion, or root entry zone. The multiple unique features of tic douloureux can be explained by a theory which is based upon presynaptic inhibition and reflection sites due to focal changes in axon diameter or myelination. We believe that this theory satisfactorily explains the varied phenomena of tic douloureux and is compatible with the limited anatomical and physiological data relevant to tic douloureux. It makes use of known physiological and anatomical concepts. It is capable of verification or refutation by experimental means.

摘要

三叉神经痛是一种人类特有的疼痛性疾病，与低等动物的疾病或其他人类疾病没有已知的相似之处。它似乎与侵犯三叉神经、半月神经节或神经根进入区的结构异常有关。三叉神经痛的多个独特特征可以用一种基于轴突直径或髓鞘局部变化导致的突触前抑制和反射位点的理论来解释。我们认为，这一理论令人满意地解释了三叉神经痛的各种现象，并且与有关三叉神经痛的有限解剖学和生理学数据相一致。它运用了已知的生理和解剖学概念。它能够通过实验手段进行验证或反驳。