摄取作为小鼠白血病中甲氨蝶呤反应的一个决定因素。
Uptake as a determinant of methotrexate response in mouse leukemias.
作者信息
Kessel D, Hall T C, Roberts D, Wodinsky I
出版信息
Science. 1965 Nov 5;150(3697):752-4. doi: 10.1126/science.150.3697.752.
PMID:5844077
Abstract
Methotrexate-promoted survival of mice bearing different transplantable leukemias was compared with uptake of the drug by leukemia cells in vitro. A high degree of correlation (r(2) = 0.88) showed that uptake may be a major determinant of the antitumor activity of methotrexate against transplantable mouse leukemias.
摘要
将甲氨蝶呤促进不同可移植性白血病小鼠存活的情况与白血病细胞在体外对该药物的摄取进行了比较。高度相关性（r² = 0.88）表明，摄取可能是甲氨蝶呤对可移植性小鼠白血病抗肿瘤活性的主要决定因素。
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