成年小鼠胸腺切除术作为增强美法仑（L-苯丙氨酸氮芥）免疫抑制作用手段的价值
On the value of thymectomy in adult mice as a means of potentiating the immunosuppressive action of Melphalan (L-phenylalanine mustard).
作者信息
Lumb G N, Symes M O
出版信息
Immunology. 1965 Dec;9(6):575-80.
Abstract
Thymectomy has been found to be ineffective as a means of potentiating the immunosuppressive action of Melphalan in adult CBA-p mice challenged with A-strain mammary carcinoma transplants. This was true when the thymectomy was performed 2 days, 4 weeks or 7 weeks prior to injection of a single dose (15 mg/kg body weight) of Melphalan, administered 24 hours prior to tumour transplantation, and also when thymectomy was combined with multiple doses of Melphalan given before and after tumour transplantation. These findings are discussed.
摘要
对于接受A株乳腺癌移植攻击的成年CBA-p小鼠，已发现胸腺切除术作为增强美法仑免疫抑制作用的手段是无效的。当在注射单剂量（15毫克/千克体重）美法仑前2天、4周或7周进行胸腺切除术（美法仑在肿瘤移植前24小时给药）时是如此，当胸腺切除术与在肿瘤移植前后给予多剂量美法仑联合使用时也是如此。对这些发现进行了讨论。
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本文引用的文献
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Skin homograft survival in thymectomized mice.胸腺切除小鼠的皮肤同种异体移植存活情况。
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